Chart showing a 77% decrease in allergic symptoms caused by ragweed when treated with BEPREVE vs a 27% decrease with placebo. Chart also shows BEPREVE treated patients experienced an 88% decrease in allergic symptoms caused by grass pollen vs 21% with placebo.

BEPREVE CALMS THE
OCULAR ITCH
CAUSED BY MULTIPLE
ALLERGENS5

BEPREVE was clinically proven to reduce ocular itch in severely allergic subjects exposed to ragweed and grass pollens as compared to placebo.*5

  • These effects were seen as early as 15 minutes after treatment.

*Study Design: Two double-masked, randomized, placebo-controlled conjunctival allergen challenge (CAC) clinical studies in which patients were assigned to receive BEPREVE (1.5%) or placebo. Analysis used the CAC model of allergic conjunctivitis, where severe response in ocular itching is defined as grade ≥3 at baseline, with a maximum score of grade 4. The primary efficacy variable was patient-evaluated ocular itching at 3, 5, and 7 minutes post challenge. Dose applied 15 minutes prior to challenge.

†The data presented above are derived from a subanalysis of the entire study population.

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Indications and Usage

BEPREVE® (bepotastine besilate ophthalmic solution) 1.5% is a histamine H1 receptor antagonist indicated for the treatment of itching associated with allergic conjunctivitis.

Important Safety Information
  • BEPREVE is contraindicated in patients with a history of hypersensitivity reactions to bepotastine or any of the other ingredients.
  • BEPREVE is for topical ophthalmic use only. To minimize risk of contamination, do not touch the dropper tip to the eyelids or to any surface. Keep the bottle closed when not in use.
  • BEPREVE should not be used to treat contact lens-related irritation. Remove contact lens prior to instillation of BEPREVE. Lenses may be reinserted 10 minutes after BEPREVE administration.
  • The most common adverse reaction occurring in approximately 25% of patients was a mild taste following instillation. Other adverse reactions occurring in 2%-5% of patients were eye irritation, headache, and nasopharyngitis.

Click here for Prescribing Information for BEPREVE.

References: 1. Meier EJ, Torkildsen GL, Gow JA, McNamara TR, Gomes PJ, Williams JI; for the Bepotastine Besilate Ophthalmic Solutions Study Group. Integrated phase III trials of bepotastine besilate ophthalmic solution 1.5% for ocular itching associated with allergic conjunctivitis. Allergy Asthma Proc. 2012;33:265-274. 2. Data on file. Clinical Study Report: CL-SAF-0405071-P. NDA 22-288. ISTA Pharmaceuticals, Inc. October 27, 2008. 3. Clark JC, Williams JI, Gow JA, Abelson MB, McNamara TR; for the Bepotastine Besilate Ophthalmic Solutions Clinical Study Group. Bepotastine besilate ophthalmic solution 1.5% rapidly eliminates ocular itching in more severely allergic subjects in the conjunctival allergen challenge model of allergic conjunctivitis. Poster presented at: 24th Annual Eastern Allergy Conference; May 6-9, 2010; Palm Beach, FL. 4. BEPREVE [package insert]. Tampa, FL: Bausch & Lomb Incorporated. June 2016. 5. Muñoz M, Williams JI, Gow JA, Schooley GL, McNamara TR; for the Bepotastine Ophthalmic Solutions Clinical Study Group. Bepotastine besilate ophthalmic solution 1.5% provides a rapid and sustained reduction in ocular itch for severely allergic subjects following exposure to ragweed or grass pollens using the conjunctival allergen challenge (CAC) model of allergic conjunctivitis. Poster presented at: 2011 Annual Scientific Meeting of the American College of Allergy, Asthma & Immunology; November 3-8, 2011; Boston, MA. Poster P341.

Indications and Usage

BEPREVE® (bepotastine besilate ophthalmic solution) 1.5% is a histamine H1 receptor antagonist indicated for the treatment of itching associated with allergic conjunctivitis.

Important Safety Information
  • BEPREVE is contraindicated in patients with a history of hypersensitivity reactions to bepotastine or any of the other ingredients.
  • BEPREVE is for topical ophthalmic use only. To minimize risk of contamination, do not touch the dropper tip to the eyelids or to any surface. Keep the bottle closed when not in use.
  • BEPREVE should not be used to treat contact lens-related irritation. Remove contact lens prior to instillation of BEPREVE. Lenses may be reinserted 10 minutes after BEPREVE administration.
  • The most common adverse reaction occurring in approximately 25% of patients was a mild taste following instillation. Other adverse reactions occurring in 2%-5% of patients were eye irritation, headache, and nasopharyngitis.

Click here for Prescribing Information for BEPREVE.

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