RAPID, LASTING, COMFORTABLE RELIEF
WITHIN MINUTES
95% of BEPREVE-treated eyes (n=156 eyes) had a rapid and clinically significant reduction of ocular itch within 15 minutes (P<0.0001)*1
8 HRS POST DOSE
90% of BEPREVE-treated eyes (n=156 eyes) maintained a clinically significant reduction (≥1 unit) of ocular itch 8 hours after allergen challenge (P<0.0001)*1
NO DISCOMFORT
92% of patients treated with BEPREVE reported no discomfort (grade 0 on a 0 to 3 ocular comfort scale) from instillation in an analysis of >6400 assessments†2
PROVEN RELIEF FOR SEVERE OCULAR ITCH
68% of BEPREVE-treated eyes (n=104 eyes) had complete relief from severe ocular itching compared to 3% of placebo-treated eyes (n=98 eyes) (P≤0.001) after 3 minutes of allergen challenge.*‡3
*Study Design: Two double-masked, randomized, placebo-controlled conjunctival allergen challenge (CAC) clinical studies in which patients were assigned to receive BEPREVE (1.5%) or placebo. Analysis used the CAC model of allergic conjunctivitis, where severe response in ocular itching is defined as grade ≥3 at baseline, with a maximum score of grade 4. The primary efficacy variable was patient-evaluated ocular itching at 3, 5, and 7 minutes post challenge. Dose applied 15 minutes prior to challenge.
†Study Design: A 6-week, multicenter, double-masked, randomized, placebo-controlled safety study in which patients (N=861) were assigned to receive BEPREVE (1.5%) or placebo. Patients self-evaluated ocular comfort of treatment immediately and 5 minutes post instillation at Visits 2 and 3 using a 4-point grading scale.
‡The data presented above are derived from a subanalysis of the entire study population.
BEPREVE OFFERS RELIEF OF ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS IN CHILDREN 2 YEARS OF AGE AND OLDER4
Safety and efficacy of BEPREVE has not been established in pediatric patients under 2 years of age. Efficacy in pediatric patients under 10 years of age was extrapolated from clinical trials conducted in pediatric patients greater than 10 years of age and from adults.4